Cliends, In my case the Roku stick remote works for everything. I can turn the TV off and on using the Stick remote and, any that ime I use the Stick remote (push any of its buttons), it will automatically switch to the Stick app. I can switch to other apps using the Stick remote although you may have to sign in to apps when opening them with the Stick remote, but only once and then it works from there as normal.
I don't think I did anything special, just went through the entire setup procedure as guided by the Stick-- I found that the Roku stick was very "smart" (I'm guessing because the TV is a Roku as well and they connect very easily)-- once I set it up the remote paired to the TV automatically.
One caveat: we do need to use a separate remote for volume control- that is because we use a TCL soundbar that for some reason can't be controlled by any of our TCL remotes.