I have had this same problem for quite some time now and I have figured out the solution. At least one that worked for me. I do have a smart TV capable of 1080p so I switched the Roku accordingly under "display type". Well that was the wrong move I had the same issue in "auto detect " as well. So 720p it is and problem went away.
I'd be happy to take a closer look to see how we can help. Can you please provide us with more specific information about the issue you are experiencing? What Roku model device are you using? Can you please specify the exact steps you are taking to reproduce this issue so we can investigate further? In addition, have you tried running the steps on this link to get your remote back up and running?
With more detailed information, we will be able to assist you further.
I am having the same problem , and I think I found my culprit. My ROKU has two ports the HDMI that goes to back of TV and other end to powersourse. it is with the OTHER port it is with this port has become loose and can no longer give a steady current answer: Get new USB power supply cable with correct type of connecting head.