Roku model 467QX received a system update on 3/26/2021 and now the volume button doesn’t work on the remote. The system has been rebooted and different batteries placed in the remote with no change.
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Have you tried re-pairing your remote again to see if that resolves your issue?
For more information about pairing your remote to your TV, visit our Support pages here:
How do I set up my Roku® enhanced remote to control my TV?
Why is my Roku® enhanced remote not controlling volume and power on my TV?