A feature called Screen Reader (renamed from Audio Guide in Roku version 10.5) announces where you are in the Roku menus for the benefit of the visually impaired. At some point you may have hit the * key on your Roku remote four times in a short period of time. This is a shortcut that toggles the Screen Reader feature on and off, so four quick presses of the * key should toggle this feature back off.
To deactivate the four-* trigger shortcut altogether use menu path Settings > Accessibility > Shortcut (in the Screen Reader or Audio Guide section) > Disabled
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