When the Roku goes to sleep (aquarium screen saver), when you wake it up, you get a terrible screeching audio. Screeching continues no matter what you do except if you reboot the Roku or do a Settings>System>Restart. Audio is then fine until it sleeps->wakeup again.
I have a new Roku Ultra model 4800X (sn S02A209NT8CN), Fiber, Cat-5 and LG TV.