A feature called Audio Guide announces where you are in the Roku menus for the benefit of the visually impaired. At some point you probably hit the * key four times in a short period of time. This is a shortcut that toggles the Audio Guide feature on and off, so four quick presses of the * key should turn the Audio Guide feature back off.
To deactivate the four-* trigger shortcut altogether use menu path Settings > Accessibility > Shortcut (in the Audio Guide section) > Disabled
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