Yes, that is an odd one. At this point we don't know if the problem is with the Roku unit or with the remote.
These things are just special purpose computers. Like their big brothers sometimes clearing things out by restarting them is all it needs.
Depending on your Roku model and Roku version number you'll find the System restart option under either Settings > System or Settings > System > Power.
Roku Community Streaming Expert
I am not a Roku employee, only a user like you. Please, no support questions via private message -- post them publicly to the Community where others may benefit as well.
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Streaming Stick 4K+ 3821 | Streaming Stick+ 3810 | TCL Roku TV 43S245/C107X