I open the remote and cut off the four as a unit (on the off chance I wanted to put them back in) and then cover the holes with a piece of clear tape. Looks fine to me. The other option would be to open the remote and put a piece of tape under the buttons so they can't make electrical contact. It's a pain to open those remotes, so it's easier to just rip/cut them out and deal with the holes.
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