This morning my Roku Ultra voice command on the remote are not responding and the programmable buttons on the remote I had set up are not working as well. They had worked a couple days ago when I set the new system up.
Try unplugging the roku, If that doesn't work, with new batteries in try re-pairing the remote to the roku. Re-pairing you won't lose the programming on 1 & 2 keys, that is stored in the roku itself.
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Thank you the repairing worked