The "point anywhere" remotes that come with Roku Streaming Stick and Streaming Stick+ control the tv power and volume directly via infrared. This is separate from the control of the Roku itself, which is done via wifi direct.
Try disconnecting the power from the Roku for a few seconds then plugging it back in. It should go to the Roku home screen when it finishes booting up on its own without any input from the remote. If it doesn't get to the home screen, this points to problems other than the remote, so post back because that will indicate other things to try.
If the Roku doesn't respond to the remote while you are viewing the home screen, you may just need to re-pair your remote to your Roku. Video from Roku re how to pair point-anywhere remote: https://www.youtube.com/watch?v=EK3T6eXqPU8oku
Roku Community Streaming Expert I am not a Roku employee, only a user like you. Please, no support questions via private message -- post them publicly to the Community where others may benefit as well. If this post solves your problem please help others find this answer by clicking " Accept as Solution.".
Streaming Stick 4K+ 3821 | Streaming Stick+ 3810 | TCL Roku TV 43S245/C107X