Usually my Harmony Companion universal remote control works fine with the Roku Premiere. Just recently I have a delay of about 7 seconds between when I press a button on the Harmony and the Roku responds. The Harmony continues to work fine with other devices in my setup, including the Xfinity box.
I have, as of today, updated software on both the Harmony and the Roku. I have also rebooted both devices. I'm stumped.