Nope, you're stuck with them being on, and the channels they are programmed for. No way to change them. Some users have disabled the buttons with internal changes to the remote.
Dan
Roku Stick (3600), Ultra (4640), Ultra (4670), Ultra (4800), Premiere (3920), Insignia 720p Roku TV, Sharp 4K Roku TV, Nvidia Shield, Windows 10 Pro x64 running Serviio and Plex on a wired Gigabit network.