Every time I turn on my TV the remote won't Work. I have to reset the Roku and then it works. If the TV is off for a while and I restart it, the same thing happens. I've changed the batteries and even bought a new remote.
Roku operating system version 10.5 added added a new "Power" item in the "Settings > System" menu for some of the latest Roku models. The new "Auto power savings" item there will put your Roku device into a low power standby condition after a period of inactivity, such as when your tv has been turned off for a while.
Pressing a Roku control key on your Roku remote (not Power, Volume, or Mute which act on the TV, not the Roku) should bring the Roku out of standby and back to full operation. Pulling the power for a few seconds to restart the Roku will restore full operation as well.
If you have a "Settings > System > Power" menu item, deactivating any power saving options you find under "Auto power savings" will prevent your Roku from going into standby in the first place.
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