My Roku does not have an Audio Guide choice. I even did a full reset of Roku and the voice is still there telling me about HDMI inputs and a bunch of gibberish.
@mikeandkim101, the Audio Guide was renamed to "Screen Reader". Do you have a Roku TV? A Roku device connected to a TV wouldn't know anything about HDMI inputs, so I would suspect your TV if it's not a Roku TV.
How do I turn off menu talking when I turn on Roku Streaming Stick+
Found my answer. Go settings. Accessability, Turn off screen reader